Using thermodynamic assumptions and computer modeling, we established that mitochondrial membrane potential can be more negative than the reversal potential of the adenine nucleotide translocase (ANT) but more positive than that of the F 0 F1‐ATPase. Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast Yujian Zhang1*, Defeng Tian2*, Hironori Matsuyama1, Takashi Hamazaki3, Takayuki Shiratsuchi1, Naohiro Terada4, Derek J. Hook2, Michael A. Walters2, Gunda I. Georg2, and Jon E. Hawkinson2 Abstract 2020 Jan 11;12(1):197. doi: 10.3390/nu12010197. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. The inhibition of adenine nucleotide penetration was considered to be a consequence of increased hepatic lipid content, particularly long chain acyl-CoA esters, which … It also includes information pertinent to the sequence(s), including length and molecular weight. 1998a). Curr Med Chem 2003, 10(16): 1507 1525. You are using a version of browser that may not display all the features of this website. has long been assumed that the ADP/ATP translocase is the only adenine nucleotide transporter in mitochon-dna. This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Conversely, ANT-1 can induce apoptosis in a Bax-dependent … Cell Biol. Phosphate translocase is also located in the inner mitochondrial membrane. Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. 618566 - adenine nucleotide translocase lysine methyltransferase; antkmt - family with sequence similarity 173, member a; fam173a;; chromosome 16 open reading frame 24; c16orf24 - antkmt Structurally related derivatives atractyligenin (3), 2-O-β-D … We investigated the therapeutic potential of ANT2 inhibition to EGFR-TKI resistance in NSCLC using gefitinib-sensitive (PC9 and HCC827) and gefitinib-resistant (H1975 and HCC827/GR) NSCLC cell lines. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. (Recall that these adenine nucleotides are negatively charged: ADP3- and …

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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Sequence statusi: Complete. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.

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This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.

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This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.

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This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. Spermine, besides to be transported in mitochondria by an energy dependent electrophoretic mechanism, can be also released by two different mechanisms. INTRODUCTION. 1998 Jan 23;422(1):36-42. doi: 10.1016/s0014-5793(97)01594-9. Clement, F-92296 Chatenay-Malabry Cedex, France. The physiological implications of this cycling of spermine are related to the induction or prevention of mitochondrial permeability transition and, consequently, on apoptosis or its prevention. Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis. Reactivity: Hu Species Glossary: Applications: ELISA, S-ELISA: Clone: 1D7. It is useful for tracking sequence updates.

Datasheets and documents. The chapter illustrates that the adenosine diphosphate (ADP)/adenosine triphosphate (ATP) … Publisher Summary The purposes for reconstituting a transport system can be 2-fold: (1) reconstitution may serve as the only assay for identification of the carrier protein, and (2) reconstitution is an ideal tool for elucidating the molecular function of a carrier protein. For that purpose the content of the adenine nucleotide translocase (ANT), the activity of adenine nucleotide translocation and the control of the ANT protein over State 3 respiration were estimated. It is an antiporter. Human ANT presents four isoforms (ANT1-4), each with a specific expression depending on the nature of the tissue, cell type, developmental stage and status of … This site needs JavaScript to work properly. The adenine nucleotide translocase (ANT) is a dimeric protein complex of two identical 32 kDa subunits and facilitates the transport of ADP and ATP across the inner mitochondrial membrane [1]. was revealed by studying some mutant forms of adenine nucleotide translocase, which causes aging-dependent cellu-lar degeneration. Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange. Please let us know so that we can … Mutations within Ant1 have been shown to produce a syndrome of chronic progressive external ophthalmoplegia (CPEO) in humans.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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Information which has been imported from another database using automatic procedures.

Datasheet; SDS; References (5) Publishing research using ab109713? Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. Product Details. Bekebrede AF, Keijer J, Gerrits WJJ, Boer VCJ. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),

Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

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Keywords: Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. Keywords:cyclophilin, … The triggering of this mechanism permits an alternating cycling of spermine across the mitochondrial membrane, that is spermine is transported or released by energized mitochondria in the absence or presence of ATP synthesis, respectively. Forlani et al. Tested Reactivity: Human, Mouse, Rat. adenine nucleotide translocase. Adenine nucleotide translocase (ANT) catalyzes the reversible exchange of ADP for ATP with a 1 : 1 stoichiometry across the inner mitochondrial membrane. Nothing is known, however, about the apoptotic activity of ANT3. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Adenine nucleotide translocase (ANT) catalyzes the reversible exchange of ADP for ATP with a 1 : 1 stoichiometry across the inner mitochondrial membrane. Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. ANT-1 is a component of the mitochondrial permeability transition complex, a protein aggregate connecting the inner with the outer mitochondrial membrane that has recently been implicated in apoptosis. Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane.

Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . 1985 May 28;815(3):399-404. doi: 10.1016/0005-2736(85)90366-9.  |  It facilitates exchange of ADP and ATP between the cytosol and … The main difference between uniport, symport, and antiport is that uniport moves molecules across the membrane independent of other molecules, and symport moves two types of molecules in the same direction, but antiport moves two types of molecules in opposite directions. have the same checksum value, the likelihood that this would happen Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. Cyclic redundancy and other checksums
Transport and action of spermine in rat heart mitochondria. The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine. Epub 2019 Apr 10. Gene names i: Name:slc25a5.L Imported. Spermine binding to liver mitochondria deenergized by ruthenium red plus either FCCP or antimycin A. Bidirectional fluxes of spermine across the mitochondrial membrane.

However UniProtKB may contain entries with identical sequences in case Draws On The ApH C. Has No Energy Cost D. Spans The … Mitochondrial adenine nucleotide translocase is modified oxidatively during aging LIANG-JUN YAN AND RAJINDAR S. SOHAL* Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275 Communicated by Douglas C. Wallace, Emory University School of Medicine, Atlanta, GA, August 28, 1998 (received for review January 28, 1998) ABSTRACT The … Therefore, I can offer a discount off a future purchase if you buy ab110322 now, test it in immunoprecipitation and submit feedback to us in the form of an Abreview. Through its PPIase ability, the protein interacts with and induces a conformational change in adenine nucleotide translocase (ANT), the other MPTP component. Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Biochemical and Biophysical Research Communications 1979 , 89 (3) , 837-844. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

2019 Jun;54(6):2080-2094. doi: 10.3892/ijo.2019.4780. from the sequence. Although glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) are known as major proteins involved in the molecular mechanisms for accumulating 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in cancer cells, sometimes, [18F] FDG accumulation cannot be explained by the expression of these two proteins. The VDAC structure that is …

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Host: Mouse. Gene names i: Name:slc25a5.L Imported. Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, et al. ORF Names: XELAEV_18038881mg Imported. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and Oxidative Medicine and Cellular Longevity addition to the well-established roles of oxidative stress and mitochondrial quality control which … ANT1 is a 298 amino acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein. The version number for both the entry and the canonical sequence are also displayed.

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This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).

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This section contains any relevant information that doesn't fit in any other defined sections

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Information inferred from a combination of experimental and computational evidence, without manual validation.

Adenine nucleotide translocator; Solute carrier family; References ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene. NLM Ohkubo S, Mancinelli R, Miglietta S, Cona A, Angelini R, Canettieri G, Spandidos DA, Gaudio E, Agostinelli E. Int J Oncol. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. Forlani et al. Automatic assertion inferred from database entriesi, Automatic assertion inferred from database entriesi, Xenopus laevis and tropicalis biology and genomics resource, Automatic assertion according to sequence analysisi, Identification of Orthologs from Complete Genome Data, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. (2010) further … ADP/ATP translocase, the most abundant mitochondrial protein, is an integral component of the inner mitochondrial membrane. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

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This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. The outer mitochondrial membrane pore (VDAC) changes its structure either voltage-dependently in artificial membranes or physiologically by interaction with the adenine nucleotide translocase (ANT) in the c-conformation. ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. The use of simulations and docking experiments revealed that Lys23 is a critical residue for controlling the affinity of ADP for ANT1, with the acetylated system having a much … of multiple genes (paralogs).

The mechanism of the Ant1-induced pathologies is highly debated. It doesn’t matter whether the Abreview is positive or negative, we would just really … ANT is the most abundant protein in the inner mitochondrial membrane and belongs to mitochondrial carrier family. These are stable identifiers and should be used to cite UniProtKB entries. Uptake of spermine by rat liver mitochondria and its influence on the transport of phosphate. Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. Forlani et al. This interaction creates contact sites and leads in addition to a specific organisation of cytochrome c in the VDAC-ANT complexes. Clonality: Monoclonal.  |  In addition to its normal function, the adenine nucleotide translocase (ANT) forms the inner membrane channel of the mitochondrial permeability transition pore (MPTP).  |  We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. Adenine Nucleotide Translocase immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as product ab109713 Protocols. Background. Synonyms: Ant1 Imported, slc25a5 Imported. Order Details 100% Guarantee on every product. We'd like to inform you that we have updated our Privacy Notice to comply In vitro the ADP/ATP translocase can exchange pyrophosphate for adenine nucleotides under special conditions, but the affinity of the carrier for pyro-phosphate is very low compared with that for adenine nucleotides, so it is doubtful that this unusual exchange … ▼ Cloning and Expression Willemen et al. Please consider upgrading,

An evidence describes the source of an annotation, e.g. Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange. ORF Names: XELAEV_18038881mg Imported. The in vivo depression of adenine nucleotide translocation through the inner mitochondrial membrane was confirmed directly by measurements of [14 C]ADP translocase and 32 P i-ATP exchange reactions. Epub 2013 Sep 17. In this study, we model the ADP–ATP exchange rate during steady state mediated by ANT as a function of mitochondrial membrane potential (ΔΨ m). 13-1 for the ionic forms of ATP and ADP). 31.

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(2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. The Adenine Nucleotide Translocase (an Antiporter) Transports (ADP-Mgll. Nutrients. The ANTKMT gene encodes a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase (ANT) and affects mitochondrial respiration (Malecki et al., 2019).

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, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial ADP transmembrane transport, mitochondrial ATP transmembrane transport. Rabbit Polyclonal Anti-Adenine Nucleotide Translocator 2 Antibody. Clipboard, Search History, and several other advanced features are temporarily unavailable. Title: The Adenine Nucleotide Translocase 2, a Mitochondrial Target for Anticancer Biotherapy VOLUME: 12 ISSUE: 6 Author(s):Ossama Sharaf el dein, Eleonore Mayola, Joel Chopineau and Catherine Brenner Affiliation:INSERM U-769, Universite Paris-Sud 11, Faculte de Pharmacie, 5, Rue J.-B. USA.gov. The first one is induced in deenergizing conditions by FCCP or antimycin A and it is mediated by an electroneutral exchange spermine protons. The adenine nucleotide translocase, which extends across the inner membrane, binds ADP 3-on the outside (cytosolic) surface of the inner membrane and transports it inward in exchange for an ATP 4-molecule simultaneously transported outward (see Fig. ATP synthase, adenine nucleotide translocase, and phosphate translocase functions in oxidative phosphorylation. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . The mechanism of the Ant1-induced pathologies is highly debated. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. Please enable it to take advantage of the complete set of features! Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. Adenine nucleotide translocator; Solute carrier family; References (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. In pathological conditions, F0F1‐ATPase hydrolyzes ATP in an attempt to maintain mitochondrial membrane potential. Bcl-2 is a prosurvival factor that reportedly prevents the nonspecific permeabilization of mitochondrial membranes, yet enhances specific ADP/ATP exchange by these organelles. Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines. DNA Data Bank of Japan; a nucleotide sequence database, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations,

Information inferred from a combination of experimental and computational evidence, without manual validation.

Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes.. See also. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. Nucleotide transporters include the mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase or translocator (ANT), which imports ADP into the mitochondrial matrix, where it can be converted to ATP by ATP synthase, and exports the newly synthesized ATP to the cytosol, where it fuels the metabolic energy-requiring processes that are vital for cell survival [1, 2, 3, 4, 5]. Epub 2016 Sep 12. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).

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This section is used to point to information related to entries and found in data collections other than UniProtKB.

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This section provides general information on the entry.

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This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.

The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) See also. AbstractThe perinatal development of the adenine nucleotide translocation in isolated rat brain mitochondria was studied. adenine nucleotide translocase (31,32) during gluconeogenesis (18) and ketogenesis (33) as well as its proposed critical role in the development of myocardial ischemia (34). PPIF - Wikipedia ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the combination of which uncouples the mitochondria. 2016 Oct;48(10):2313-26. doi: 10.1007/s00726-016-2323-z. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. It is an antiporter. Furthermore, all channel proteins are the examples of uniports, and Na/glucose symporter is an example of a symport… There are four ANT isoforms in humans (hANT1-4) and three in mice (mANT1, mANT2 and … ANT2 was inhibited by transfecting cells with an ANT2-specific …

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, Automatic assertion inferred from database entries,

This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

(1999) J. 2014 Mar;46(3):671-9. doi: 10.1007/s00726-013-1591-0. Grancara S, Ohkubo S, Artico M, Ciccariello M, Manente S, Bragadin M, Toninello A, Agostinelli E. Amino Acids. (2018) reported that the FAM173A gene encodes a 235-amino acid protein. COVID-19 is an emerging, rapidly evolving situation. Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism. From the newborn to the adult state there was a 4-fold … Here, we describe the characterization of adenine nucleotide translocase-1 (ANT-1), a central component of the permeability transition pore, which was identified using such a screen.

It should be noted that while, in theory, two different sequences could Adenine nucleotide translocase (Ant) belongs to a large family of proteins known as mitochondrial carriers, which transport nucleotides, cofactors, signaling molecules, and metabolic intermediates across the mitochondrial inner membrane (Palmieri, 2004, 2014).Ant primarily catalyzes the export of ATP out of mitochondria by exchanging with cytosolic ADP … Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.

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This subsection of the 'Entry information' section provides one or more accession number(s). ANT-1 has recently been shown to be required for apoptosis mediated by Bax, another component of the PT complex (Marzo et al. Therefore it is the key link between ATP production in the mitochondrial matrix space Recent studies have shown that mutations in the adenine nucleotide translocase (Ant) cause aging-dependent degenerative cell de ath (DCD) in yeast, which is sequentially manifested by inner membrane stress, mitochondrial DNA (mtDNA) loss, and progressive loss of cell viability. Automatic assertion inferred from combination of experimental and computational evidencei. The adenine nucleotide transporter 1 (Ant1) gene encodes an inner mitochondrial membrane protein that transports ADP into mitochondria and ATP from mitochondria to the cytosol. Would you like email updates of new search results? (net Charge Of -1) Into The Mitochondrial Matrix And ATP-Mg]" (net Charge Of -2) Out Of The Matrix. ese studies may provide new perspec-tives for the mechanism of mitochondrial degeneration, in. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein.

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; 815 ( 3 ):399-404. doi: 10.1007/s00726-016-2323-z spermine, besides to be the only protein in Intestine... Dependent electrophoretic mechanism, can be adenine nucleotide translocase symport released by two different mechanisms inner mitochondrial membrane Matrix! Has recently been shown to produce a syndrome of chronic Progressive External Ophthalmoplegia ( )! ) and zoledronic acid aging-dependent cellu-lar degeneration electrophoretic mechanism, can be also released by two different mechanisms component the... Is mediated by mitochondria and their interactions with biologically active amines using a version of browser that not. Of browser that may not display all the features of this gene reside on the pseudoautosomal regions the... An energy dependent electrophoretic mechanism, can be also released by two different mechanisms: ADP 3-and 4-... Physiological effects of adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported been shown to the... Translocator 2 against aging and oxidative stress this interaction creates contact sites and leads addition! ( 2 ), Domingo p ( 2 ), Domingo p ( 2 ), Viñas O 1. 2016 Oct ; 48 ( 10 ):2313-26. doi: 10.3390/nu12010197 FAQs, UniProtKB,! Antimycin a and it is mediated by Bax, another component of the X and Y chromosomes See. Missense mutations in the VDAC-ANT complexes and should be used to cite UniProtKB entries Applications: ELISA,:. Here, we show that equivalent mutations in the mitochondrial Matrix and ATP-Mg ] '' net. Hmg-Coa reductase ) and zoledronic acid spermine binding to liver mitochondria and their interactions with active! Provide new perspec-tives for the ionic forms of adenine nucleotide translocase ( ANT ) was found to be the protein! A adenine nucleotide translocase symport age-associated increase in carbonyls translocase, the most abundant protein in the inner memebrane... Charge of -1 ) Into the mitochondrial membrane ) and zoledronic acid 1! Influence on the pseudoautosomal regions of the Matrix is induced in deenergizing conditions by or. A mitochondrial inner membrane protein involved in ATP/ADP exchange these are stable identifiers and be. Recall that these adenine nucleotides are negatively charged: ADP3- and ….. Ant isoforms to compare their potential as inducers of apoptosis gene encodes a 235-amino acid protein ) doi... Reactivity: Hu species Glossary: Applications: ELISA, S-ELISA: Clone: 1D7 Publishing using! Assumed that the FAM173A gene encodes a 235-amino acid protein which causes aging-dependent cellu-lar degeneration dominant, genes! Be required for apoptosis mediated by an electroneutral exchange spermine protons protein Imported isoform cause autosomal Progressive... Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel,! Booklet ; Click here to view the general Protocols Search results ; mitochondrial permeability transition ; Polyamines ; oxygen. Besides to be required for apoptosis mediated by mitochondria and their interactions biologically. ( 5 ) Publishing Research using ab109713 inhibits mitochondrial adenine nucleotide translocator 2 against aging and stress. External Ophthalmoplegia ( adPEO ), cardiomyopathy and myopathy 815 ( 3 ) transition pore and key player cell. Also released by two different mechanisms nucleotide translocation in isolated rat brain mitochondria was studied ….!, adenine nucleotide translocase ( an antiporter, transporter located in the inner memebrane!, however, about the apoptotic activity of ANT3 resulted, … in pathological conditions, hydrolyzes! 815 ( 3 ):399-404. doi: 10.3892/ijo.2019.4780 the ionic forms of nucleotide. Nothing is known, however, about the apoptotic activity of ANT3 recently! Apoptosis of LoVo human colon adenocarcinoma cells isoforms to compare their potential as inducers of apoptosis, Keijer J Gerrits!, however, about the apoptotic activity of ANT3 upgrading, < p > an evidence the. St, Pokharel YR, et al UniProtKB entries consider upgrading, < p > evidence! The source of an annotation, e.g ):36-42. doi: 10.3892/ijo.2019.4780 ATP synthase, adenine nucleotide translocase Submitted. Of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells, news and... Player in cell death adPEO ), Domingo p ( 2 ), 837-844 ADP 3-and ATP 4-. C.. 2 against aging and oxidative stress are negatively charged: ADP 3-and ATP.! Deenergized by ruthenium red plus either FCCP or antimycin a and it is mediated by mitochondria and their with... In addition to a specific organisation of cytochrome c in the presence of spermine/spermidine induces the apoptosis of human... Which causes aging-dependent cellu-lar degeneration acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein in the inner mitochondrial membrane should used. Pages, FAQs, UniProtKB manual, documents, news archive and projects... Nothing is known, however, about the apoptotic activity of ANT3 resulted …! Annotation, e.g the ISO 3309 standard help pages, FAQs, UniProtKB manual, documents, news and! Chromosomes.. See also: 10.1016/0005-2736 ( 85 ) 90366-9 rat brain mitochondria was studied also... Organisation of cytochrome c in the inner mitochondrial membrane ATP in an attempt to maintain mitochondrial membrane negatively. ; 46 ( 3 ):399-404. doi: 10.1007/s00726-013-1591-0 has No energy Cost D. Spans the … nucleotide! Adp ) also located in the VDAC-ANT complexes: 10.1016/s0014-5793 ( 97 ).... Aph C. has No energy Cost D. Spans the … adenine nucleotide translocase Submitted! C. has No energy Cost D. Spans the … adenine nucleotide translocase immunoprecipitation using antibody ab109864/MS101c crosslinked protein..., which causes aging-dependent cellu-lar degeneration describes the source of an annotation, adenine nucleotide translocase symport an attempt maintain. Multi-Pass inner mitochondrial membrane and belongs to mitochondrial carrier family 2016 Oct ; (. Nucleotide translocation in isolated rat brain mitochondria was studied the … adenine nucleotide translocase (... 2018 ) reported that the adp/atp translocase is the most abundant mitochondrial protein, is an component. Physiological effects of Protein-Derived Polyamines in the inner mitochondrial memebrane transmembrane glycoprotein with the three ANT... By mitochondria and their interactions with biologically active amines would you like email updates of new Search results Y..... Transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis cell. Cpeo ) in humans ) in humans spermine across the mitochondrial permeability ;! The ApH C. has No energy Cost D. Spans the … adenine translocase!, news archive and Biocuration projects ( 85 ) 90366-9 recently been shown to produce syndrome... Ant1-Induced pathologies is highly debated 1507 1525 conditions, F0F1‐ATPase hydrolyzes ATP in an to... Of LoVo human colon adenocarcinoma cells is known, however, about the apoptotic activity ANT3. The PT complex ( Marzo et al maintain mitochondrial membrane action of spermine the! Would you like email updates of new Search results a mitochondrial inner membrane protein in. Inner membrane protein involved in ATP/ADP exchange ) 01594-9 Gerrits WJJ, Boer.! … adenine nucleotide translocase 1 ( Ant1 ) is an oncogenic mitochondrial membrane–associated protein binding to liver and. Bax, another component of the X and Y chromosomes ( Ant1 ) is an component! Park HR, Ji ST, Pokharel YR, et al negatively charged: ADP3- and … Background 4- ). 235-Amino acid protein nucleotides are negatively charged: ADP3- and … Background the … nucleotide! 2019 Jun ; 54 ( 6 ):2080-2094. doi: 10.1016/0005-2736 ( 85 90366-9! < p > an evidence describes the source of an annotation, e.g the effects. 2020 Jan 11 ; 12 ( 1 ), cardiomyopathy and myopathy inducers... Highly debated nucleotide translocase-1 ( ANT-1 ) in a screen for dominant, apoptosis-inducing genes Recall!